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A mutation in the DNA binding domain of a steroid hormone receptor is most likely to affect the


A) conformational change of the receptor.
B) binding of the hormone to the receptor.
C) translocation of the receptor to the nucleus.
D) cellular response to the hormone.

E) A) and C)
F) B) and C)

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Hormones are an example of intercellular communication known as _____________ signaling.


A) neural
B) endocrine
C) paracrine
D) autocrine

E) A) and C)
F) B) and C)

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In the digestive tract adjacent cells develop connections to form a sheet that prevents leakage of small molecules.These connections between cells are called


A) communicating junctions.
B) desmosomes.
C) gap junctions.
D) ion gates.
E) tight junctions.

F) C) and E)
G) B) and C)

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Leptin is a hormone that is produced by fat cells and plays a role in body metabolism and obesity.Studies have demonstrated that when obese mice are injected with leptin they quickly lose their excess weight.Interestingly,however,many overweight people have high levels of leptin in their bloodstream.Which of the following explanations is most consistent with this observation?


A) Paracrine signaling may be disrupted in obese people with high levels of leptin.
B) Obese people who have high levels of leptin may have a defective leptin receptor.
C) The form of leptin released by obese people may lack protein kinase activity.
D) In obese people with high levels of leptin,the leptin is binding to the wrong receptor.

E) None of the above
F) A) and C)

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The protein SOS is a guanine nucleotide exchange factor for Ras.SOS helps facilitate the exchange of GDP for GTP.What would be the effect of a mutation that inhibits the interaction between SOS and Ras?


A) GTP would remain bound to Ras,thereby disrupting downstream signaling events.
B) GDP would remain bound to Ras,thereby disrupting downstream signaling events.
C) GTP would remain bound to Ras,leading to overstimulation of the Ras pathway.
D) GDP would remain bound to Ras,leading to overstimulation of the Ras pathway.

E) A) and D)
F) A) and C)

Correct Answer

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A researcher is investigating several MHC proteins.That means she is


A) studying proteins similar to G-protein-coupled receptors.
B) studying proteins that provide surface markers for distinguishing between "self" and "non-self" cells.
C) studying proteins that are commonly used to detect human blood groups (A,B,AB,and O) .
D) studying proteins that act as second messengers.

E) None of the above
F) B) and C)

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Chemically-gated ion ________ open or close when signal molecules bind to the channel,allowing specific ions to diffuse through the channel.


A) channels
B) molecules
C) species
D) membranes

E) None of the above
F) B) and C)

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Which of the following is not part of the cell communication system in animal cells?


A) gap junctions
B) plasmodesmata
C) tight junctions
D) desmosomes

E) A) and C)
F) None of the above

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Short-lived,causing local effects.


A) paracrine signaling
B) direct contact
C) endocrine signaling
D) synaptic signaling

E) A) and D)
F) B) and C)

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The protein Sonic Hedgehog (SHH) plays a role in specifying the identity of digits (such as fingers,etc. ) in mammals.Several digits arise directly from cells that both express and respond to secreted SHH.In this case,SHH is acting as


A) a direct contact signal.
B) an endocrine signal.
C) a paracrine signal.
D) an autocrine signal.

E) A) and B)
F) All of the above

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A mutation that affects Ca++ binding to calmodulin is most likely to interfere with which aspect of a signal transduction pathway?


A) the flow of Ca++ ions through ion channel receptors
B) the cellular response to the second messenger
C) MAP kinase cascade
D) G protein activity

E) A) and B)
F) A) and C)

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A biochemist is designing a new drug that will mimic the shape and function of a particular signal molecule.Therefore she must produce a molecule that will bind to the receptor protein and


A) induce a change in the receptor molecule shape,which will ultimately prevent a cellular response.
B) induce a change in the receptor molecule shape,which will ultimately produce a cellular response.
C) induce a change in the phospholipid bilayer that causes a polar reversal allowing the molecules to be endocytosed.
D) produce a cellular response by altering the Na+/K+ pump located near the receptor site.

E) A) and B)
F) A) and C)

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Chemically-gated ion channels are receptor proteins through which ions pass.A cell biologist has blocked these channels in a lab rat's liver tissue by using a chemical that


A) prohibits binding of a signal molecule.
B) prohibits ions from entering the cell via active transport.
C) causes ions to move in the opposite direction of the ion gradient.
D) prohibits second messenger signaling.

E) All of the above
F) B) and C)

Correct Answer

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In plants,cell-cell junctions can only occur at gaps in the cell walls through cytoplasmic connections that form across the plasma membranes of the touching cells.These junctions are called


A) desmosomes.
B) tight junctions.
C) plasmodesmata.
D) the cellulose matrix.
E) adhering junctions.

F) B) and D)
G) All of the above

Correct Answer

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Signals with short-lived,local effects are called


A) direct contact.
B) endocrine signals.
C) paracrine signals.
D) synaptic signals.
E) light signals.

F) A) and D)
G) A) and E)

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Tight and anchoring _______ cause cells to adhere tightly to each other.


A) cells
B) proteins
C) signals
D) junctions

E) A) and B)
F) None of the above

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The molecules that convert extracellular signals into intracellular ones are


A) neurotransmitters.
B) peptide hormones.
C) cell surface receptors.
D) growth factor proteins.
E) genes.

F) C) and D)
G) A) and E)

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Communication between cells can occur by all of the following basic mechanisms except


A) direct contact.
B) intracellular signaling.
C) paracrine signaling.
D) endocrine signaling.
E) synaptic signaling.

F) A) and C)
G) A) and D)

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All of the following statements about chemically-gated ion channels are true except


A) their amino acid chains wind back and forth across the membrane.
B) they close in response to binding of the signal molecule.
C) a pore exists in the center of the protein.
D) the pore connects the extracellular fluid with the cytoplasm.
E) the pore is big enough for ions to pass through it.

F) A) and C)
G) B) and E)

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Synaptic signaling requires which of the following to be released into the synaptic gap?


A) hormones
B) internal receptors
C) genes
D) neurotransmitters
E) lipids

F) A) and D)
G) C) and D)

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